The Supreme Court of Ghana is the highest judicial body in Ghana. 

Ghana's 1992 constitution guarantees the independence and separation of the Judiciary from the Legislative and the Executive arms of government. It has exclusive original jurisdiction in all matters relating to the enforcement or interpretation of the 1992 Constitution. It also has supervisory jurisdiction over all the Courts in Ghana. It is located only at the Headquarters in Accra. 

The Supreme Court was established by the Supreme Court Ordinance of 1876 as the highest tribunal in the Gold Coast during the colonial era. Appeals from the Supreme Court went to the West African Court of Appeals (WACA) established in 1866. Ghana withdrew from WACA after attaining independence. 

After the military coup d'état of February 24, 1966, the National Liberation Council (NLC), by the Courts Decree, 1966 (NLCD.84) abolished the Supreme Court and vested judicial power in two sets of courts, Superior Court of Judicature and the inferior Courts. This was reversed by Article 102(4) of the 1969 constitution establishing the second republic. 

After the coup on January 13, 1972, the Supreme Court was again abolished by the National Redemption Council with the reason that the 1969 constitution had been suspended and so there was no need for a court to "interpret and enforce it". The Court of Appeal then became the highest court in Ghana and so the functions of the supreme court were transferred to court of appeal. 

This was again reversed by the 1979 constitution when the third Republic was established on September 24, 1979. The Supreme Court was left intact after the December 31, 1981 coup by the Provisional National Defence Council, though it made changes to the court system by introducing public tribunals. 

The 1992 constitution stipulates that the Supreme court is made up of the Chief Justice and not less than nine other Justices of the Supreme Court. The Chief Justice is appointed by the President of Ghana in consultation with the Council of State following Parliament’s vetting and approval. The Chief Justice presides over all sittings of the supreme court and oversees the administration of both the superior and the inferior courts. In his absence the most senior of the Justices of the Supreme Court, as constituted shall preside  

The other Supreme Court Justices are appointed by the President acting on the advice of the Judicial Council and in consultation with the Council of State. This must also be with the approval of Parliament. 

The 1992 Constitution abolished all the public tribunals established under the PNDC law and created the Regional Tribunal whose chairman was equated with the High Court judge.